Also Known As ALCAR, Acetylcarnitine
  • Cholinergic
Good for
  • Energy
  • Learning
  • Memory
  • Motivation
Stacks Well With
  • Aniracetam
  • Noopept
  • Piracetam
  • Pramiracetam
Dosage 500 mg
Half-life 1-4 hours

Acetyl L-Carnitine (ALCAR) is a form of nootropic available as a supplement that supports both the body and the mind. This powerful amino acid helps boost our energy levels and protect the brain from early signs of aging. Apart from treating multiple health-related problems, ALCAR nurtures the nerve functions by providing cognitive, memory and mood benefits.


Acetyl L-Carnitine, also known as MRM, Methylation and ALCAR, is an amino acid that turns fat into energy. Despite the fact that ALCAR is actually a processed form of carnitine, a compound commonly used as a physical performance supplement, it has very different effects because its primary functions are closely related to brain mechanisms.

Although ALCAR doesn’t belong to a group of essential nutrients because the body can naturally gain similar properties from food rich in protein, a carnitine supplement can improve energy production and general health. For that reason, ALCAR has become quite a popular supplement for promoting proper muscle and brain development, while also being widely used as a treatment for muscle diseases, heart conditions, infertility, and nerve disorders.

Carnitine was first isolated from meat in 1905, but now it’s believed that this acetylated form of Lysine naturally occurs in animals and plants as well. That being said, the acetylated version is more commonly used because it offers a better bioavailability ratio than any other form of L-carnitine. In fact, contrary to other forms, ALCAR bypasses the blood-brain barrier and reacts directly within the brain.

As the main focus of ALCAR is the production of acetylcholine – one of the main neurotransmitters responsible for memory, learning, perception, and other cognitive processes – this type of supplement enhances memory formation and promotes increased synaptic plasticity. This especially applies when stacked with other nootropics and supplements such as choline.

Since Acetyl L-Carnitine has been excessively studied, the results show no negative side-effects, which is why it is available without a prescription as a nutritional supplement. In addition, combining ALCAR with other nootropics is also recommended, as the joint compounds perform better and efficiently complement each other.

Difference between Acetyl L-Carnitine and L-CarnitineAcetyl L-Carnitine Review: Benefits, Dosage, Stacking and Side Effects

As already mentioned, ALCAR and L-carnitine are two different forms of the same amino acid (lysine) with different workings and effects. While both L-carnitine versions support muscles, as well as the the nervous and cardiovascular system, L-acetylcarnitine can help energize the brain, support nerves, and promote synthesis of acetylcholine.

L-carnitine, on the other hand, is mainly used as an enhancement for weight loss and workouts, due to the fast muscle recovery and energy boost offer by its fat burning properties. While ALCAR also possesses the same ability to convert fat into energy, its primary benefit is related to the mind. Still, one can mix and use both supplements in order to gain energy and protect their memory.

Since Acetyl L-Carnitine has been excessively studied, the results show no negative side-effects, which is why it is available without a prescription as a nutritional supplement

There are no health risks of taking these aminos together, but it might not be necessary. Since ALCAR provides the same effects as L-carnitine and much more, it’s better to consider some other nootropic-ALCAR combination. However, ALCAR it works well with nootropics like racetams due to their similar roles that complement each other.

Then again, these two carnitine forms are not the only available choice. Additional versions such as Acetyl-L-Carnitine, L-Carnitine Tartrate, L-Carnitine Fumarate, GPLC, and ArginoCarn also provide the muscular, cardiovascular, and nervous system protection. Nevertheless, to make the right supplement decision, consider the particular functions of each of these options.

Acetyl L-Carnitine Ingredients in Action

Acetyl L-Carnitine Review: Benefits, Dosage, Stacking and Side EffectsFirst of all, the Acetyl L-Carnitine supplement comes in several forms, but due to their bioavailability, each of these nootropic solutions quickly find their way into the body’s bloodstream. Once ALCAR is synthesized in the liver and kidneys, it then gets transported to other tissues. However, given ALCAR’s unusual ability to rapidly cross over the blood-brain barrier, its unique and vital actions start to occur directly in the brain.

So what really happens to the mind when it settles there? Well, ALCAR’s most significant function begins to evolve. The nootropic provides the basis for the neurotransmitter acetylcholine and the levels of the “learning neurotransmitter” begin to rise. Meaning that cognitive functions get a helping hand that does more than simply enhancing memory. Increased acetylcholine levels protect the brain from the risks of Alzheimer’s and Parkinson’s diseases.

Moreover, ALCAR has also been known for its mood improving properties via increased levels of serotonin and norepinephrine. These are also crucial neurotransmitters because of their role in brain function and our frame of mind.

Still, the Acetyl L-Carnitine benefits don’t end here, as it affects the brain metabolism as well. In fact, it energizes the cells, reduces the amount of damaged cells, and fights against cellular oxidation due to its strong antioxidant properties.

That’s right, ALCAR is a powerful antioxidant which helps the brain eliminate damaged cells that often lead to neurological disorders. For example, lipofuscin, commonly known as “age spots”, are the damaged fat brain cells that negatively influence memory, energy, and the nervous system. Although they are associated with age, ALCAR can protect the mind from deterioration. The same advantages relate to people under a lot of stress, because anxiety and tension kill off brain cells.

The most fascinating advantage, however, comes from ALCAR’s power to tighten the protective myelin sheath that surrounds the nerves in the brain. Any type of myelin damage could affect balance, vision, hearing, and brain health in general.

Nonetheless, ALCAR’s perks continue in the body with fat-to-energy conversion and increased metabolic functions. Due to its L-carnitine properties, ALCAR is efficient in reducing hypertension and blood pressure.

Acetyl L-Carnitine Effects and Benefits

Acetyl L-Carnitine Review: Benefits, Dosage, Stacking and Side EffectsALCAR is frequently used in medical treatments to slow down and recover the loss of functions with numerous neurological disorders and various medical conditions. The range of Acetyl L-Carnitine benefits is not solely limited to the brain, because this natural compound rejuvenates and maintains the health of the entire body.

Memory & Verbal Skills

Time after time, numerous studies have found that elderly patients who consume ALCAR supplements perform better on tests on verbal and direct memory skills. Some studies even claim that ALCAR brings new life to aging mitochondria, which can contribute to age-related problems like memory loss, Type 2 diabetes and Parkinson’s disease. Since memory loss is directly related to mitochondrial decay and RNA/DNA oxidation, patients experience a partial reversal as a result of Acetyl L-Carnitine consumption.

This powerhouse protects the brain’s nerve cells from damage caused by oxygen deficiency. Therefore, it is not unusual for stroke patients to receive the ALCAR treatment immediately after the stroke. Actually, researchers have proven that patients experience neuroprotective effects and improved recovery as a result of Acetyl L-Carnitine usage after a stroke.

ALCAR acts as a neuroprotectant and patients with Alzheimer and Parkinson’s diseases have a promising cognitive intervention. The key findings show that this supplement improves neural function and slows the rate of further brain degradation.

For people with Type 2 diabetes L-acetylcarnitine provides the much-needed control and prevents further memory decline. Also, patients with the proper nootropic medication can efficiently restore balance and reduce the pains of nerve endings.

Cognitive Enhancer

ALCAR has also been proven to enhance cognitive abilities. An additional set of study reports demonstrate that it successfully improves cognitive function and reduces mental fatigue. While ALCAR enhances the acetylcholine system, it also increases learning abilities.

There are also some indications that ALCAR can improve cognitive abilities of students as well. This makes sense, because the nootropic’s cognitive effects were also confirmed by many more scientific examinations.

ALCAR is a powerful antioxidant which helps the brain eliminate damaged cells that often lead to neurological disorders

Elevated Mood   

Acetyl L-Carnitine is also an excellent anti-depressant. Hence, those struggling with anxiety, phobias, sleep disturbances, mood swings and other mood related issues can benefit from ALCAR’s mood elevating effects. A crossover Italian study found that L-acetylcarnitine treatment is highly effective for patients dealing with such conditions and that the drug use didn’t show any side-effects.

Because of its antioxidant properties, ALCAR helps to detoxify the brain and straighten the nerves. So it comes as no surprise that this supplement is often used for problems related to alcoholism, because it improves the neural network and protects the mind from the harmful effects of alcohol.


With ALCAR’s profound effects on the mitochondria, the signs of aging are drastically diminished. The results from a 2011 study suggest:

“A significant age-related change occurred in 31 proteins involved in several metabolisms. ALCAR supplementation altered the levels of 26 proteins. In particular, ALCAR reversed the age-related alterations of 10 mitochondrial proteins relative to mitochondrial cristae morphology, to the oxidative phosphorylation and antioxidant systems, to urea cycle, to purine biosynthesis.”

So it is safe to conclude that Acetyl L-Carnitine not only fights off free radicals, but also makes strong changes in terms of age damage in the process.

Physical Health

For those individuals interested in physical benefits of ALCAR supplementation, there are several bodily health advantages of ALCAR use, including:

More Energy – L-carnitine is an adequate dietary addition for bodybuilding, however, L-acetylcarnitine is a more beneficial supplement due to its ability to burn fat and increase the amount of fat available for energy.

Infertility – ALCAR is a beneficial treatment for infertility among males, because it increases the sperm count and movement. It also helps to elevate men’s hormone levels, so testosterone deficiency is successfully taken care of via Acetyl L-Carnitine.

Cardiovascular Health – ALCAR promotes heart health and significantly reduces the risk of heart failure and death.

Reduces Pain – Apart from reducing (neuropathy) nerve pain, ALCAR reduces pain and prevents worsening in people with diagnosed Peyronie’s disease.

Acetyl L-Carnitine Side Effects

This nootropic is considered very safe for almost all and therefore, there are no dangerous Acetyl L-Carnitine side effects, though some mild and quite rare side-effects such as headaches, nausea, stomach discomfort, and diarrhea can occur in exceptional cases. Still, there have been no recorded cases of unsafe consequences from using or even overdosing on ALCAR.

If you are pregnant or breastfeeding, you should avoid the use of nootropics, because the effects on unborn and newborn children have not been thoroughly tested yet. It is also advised that individuals with a history of seizures or problems with thyroid hormones should not use this supplement.

Acetyl L-Carnitine Dosage & Stacking

Acetyl L-Carnitine Review: Benefits, Dosage, Stacking and Side EffectsBefore taking any type of supplement it is recommended that you consult a doctor. However, general guidelines on Acetyl L-Carnitine dosage suggest that the proper average intake should be somewhere between 500-1000 mg taken two or three times per day. Whereas people with diagnosed Alzheimer’s, diabetes, depression, or memory loss require a larger dosage of about 1400-3000 mg daily.

In addition, it is preferred to stack this compound with other brain supplements with similar properties to increase the majority of its health benefits. Any acetylcholine enhancers will work well with ALCAR, hence, nootropic supplements from the Racetam family will complement the Acetyl L-Carnitine effects.

Of course, the greatest benefits come from Acetyl L-Carnitine stacking with the proper dose of Chlorine, Choline Citrate, and Choliine Bitartrate in particular, but be sure to use a smaller dosage if you decide to go with stronger chlorine supplements such as Alpha GPC and CDP Chlorine to avoid headaches.

We suggest starting with a dose of 500 mg ALCAR and stacking it with 4 grams of Piracetam and 1 gram of Alpha GPC. Those who want to gain maximum strength for an efficient workout should aim to take 1.5 grams of Acetyl L-Carnitine twice a day and boost their dietary regimen with 2-3 grams of fish oil and 300 mg of the ALA antioxidant.

User Experience

Acetyl L-Carnitine Review: Benefits, Dosage, Stacking and Side EffectsAccording to the majority of Acetyl L-Carnitine reviews, people worldwide express their utter content with ALCAR. From satisfied students who recommend the use of Acetyl L-Carnitine for mental clarity and academic achievements, to the bodybuilding community, everyone highly endorses ALCAR.

The nootropic buzz still continues as more people join the ALCAR club each day. Some compare it to the miracle drug in the movie Limitless, but of course, without the negative impact.

Where to Buy Acetyl L-Carnitine

Amazon is an excellent place to explore all of the Acetyl L-Carnitine options. Although ALCAR supplements come in a liquid, powder, capsule, and tablet form, some of the highest rated options (5-star ratings) are Divine Bounty products like the 1200 mg Acetyl L-Carnitine Capsules. These capsules are ideal for stressed and overworked individuals because they help with chronic fatigue and support natural energy production.

Buy from Divine Bounty ALCAR

Another quality nootropic supplement is the Highest Potency Acetyl L-Carnitine HCl Supplement  from Vitamorph Labs that improves energy, mental capacity, fat metabolization and fat loss. So this might be more appropriate for those dedicated to an efficient training regime.

Buy from Vitamorph Labs


Acetyl L-Carnitine is a natural compound and it’s a supplement for the future. It increases productivity, improves general health, and effectively slows down the aging process of the brain, while improving the user’s overall state of mind.

With such a large base of satisfied consumers, there is no question that anyone who wants to enhance and protect their brain and body should definitely consider trying Acetyl L-Carnitine. After all, there are no harmful side-effects, only the gentle nourishment of one of nature’s finest ingredients.


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