Also Known As Citicoline, Ceraxon
  • Cholinergic
Good for
  • Focus
  • Learning
  • Memory
Stacks Well With
Dosage 250-750 mg
Half-life 60-70 hours

CDP choline is a widely used nootropic. It is a natural compound renowned for its beneficial effects. It is often used to fight neurological disorders, alleviate symptoms of head trauma and during ischemia. CDP choline also has anti-addictive and cognitive boosting effects. This is why it is the preferred nootropic with people suffering from memory disorders.


CDP choline (cytidine diphosphate-choline) is also known as Citicoline. In the world of biochemistry, it is known as cytidine 5’-diphosphocholine, and this molecule is an intermediate. This means that it is synthesized in the process of phosphatidylcholine generation from choline, which occurs in cell membranes naturally, with both animals and humans. It is a compound that belongs in the choline-containing phospholipids category and it can be ingested orally.

When ingested, it introduces two molecules to our bodies – choline and uridine. The process of CDP choline digestion breaks down this molecule into cytidine and choline. Cytidine is then converted into uridine. This supplement is known for its positive effects in the treatment of memory impairments, and both uridine and choline have been linked to better learning. Besides, they act as neuroprotective molecules, further enhancing the effect CDP choline has on our learning capacity.

Multiple studies have linked CDP choline intake with better cognitive performance, and students often use it as a memory enhancer during exam periods. Some studies have also established a link between CDP choline intake and increased attention, and this compound is also known to have anti-addictive effects – studies have confirmed that CDP choline can help fight both food and cocaine addictions.

Cdp Choline Benefits and Effects

CDP choline is a very powerful and commonly used nootropic supplement that is able to improve brain health and enhance specific aspects of cognition. Here are some benefits and effects linked to CDP Choline.

Enhances the Effects of Other Nootropics. People who regularly use nootropics have come to the conclusion that CDP choline is the key ingredient of nootropic stacks and should be considered a must-have supplement when combining other supplements to get enhanced effects.

When taken with nootropics from the racetam category, CDP choline makes their effect even stronger while preventing side effects related to racetam intake, such as minor headaches. A study has also shown that taking piracetam with CDP choline delays the symptoms of Alzheimer’s disease, specifically the cognitive deterioration ones.

Improves Memory and Prevents Memory Loss. There is not a study of CDP choline and its effects that haven’t concluded that it has the ability to improve memory and prevent memory loss. Since researchers have associated CDP choline with anti-aging effects, scientist are now devoted to identifying the therapeutic effects of CDP choline in Alzheimer’s disease.

Increased Focus and Enhanced Concentration. When it comes to completing complex tasks, not only does one have to be mentally engaged, but also remain focused and concentrated on the task at hand. CDP choline has the ability to help by increasing focus and enhancing concentration.

It can be used by people who have to remain concentrated over long periods of time, or those who experienced a stroke or brain injury and have problems with focus and concentration. The studies have confirmed that these patients can use CDP choline to achieve a significant improvement.

Increased levels of Mental Energy. As you know, we all have a limited amount of mental energy that diminishes as the day goes by. Well, CDP choline increases mental energy levels and allows people to maintain high concentration levels during their everyday activities. CDP choline can be also used to mitigate the effect that aging has on mental energy.

It Helps Repair Brain Cells. CDP choline also exhibits a neuroprotective effect, i.e. it helps with repair brain cells. The brain cells can be damaged due to many factors, the main one being environmental stress. Since CDP choline is an antioxidant as well, i.e. it removes free radicals from our body, it also protects brain cells from excessive damage.

It Improves Visual Function. There are studies suggesting that CDP Choline has beneficial effects for patients with glaucoma. CDP choline improves the visual function of these patients and helps them with some of the major symptoms related to this condition.

How Cdp Choline Works

CDP Choline Review: Benefits, Dosage, Stacking and Side Effects

Since CDP Choline was the subject of many studies, we are now completely aware of its functions and the processes it is involved in. It has been classified as a psychostimulant nootropic with several functions:

• It helps in repairing and restoring building blocks of neural cell membranes
• It affects the balance of dopamine in the central neural system by increasing its production
• It increases the production of acetylcholine, another very important neurotransmitter

After coming into the body, CDP choline is broken down into cytidine and choline. Then, due to its small molecule size, it easily crosses the blood-brain barrier. It is important to note that our body immediately converts cytidine into uridine, a compound that has a positive effect on the neural membrane and cognition.

Since our brains prefer to use choline when acetylcholine has to be synthesized, there is a very limited amount of choline available for phosphatidylcholine synthesis. What’s even worse, when our brain needs choline, it takes it from neuronal membranes. This happens during ischemia, and the result of this process are lots of free radicals (hydroxyl radicals).

CDP choline can be used by people who have to remain concentrated over long periods of time, or those who experienced a stroke or brain injury and have problems with focus and concentration.

Taking the CDP choline supplement ensures that there is enough choline in our bloodstream that our brain can use to synthesize acetylcholine and rebuild phospholipids stores in neuronal membranes depleted by ischemia.

CDP choline also affects the system in charge of neuronal membrane stabilization. It reduces the levels of arachidonic acid and helps maintain perfect balance on the micro level for our well-being.

CDP choline stimulates the production of specific neurotransmitters – dopamine, norepinephrine and acetylcholine – and with more available neurotransmitters, our cells can communicate more easily and faster. Simply put, CDP choline improves cellular communication.

CDP Choline Dosage

Before we jump right to the dosage, it is important to get one thing clear – CDP choline is water soluble. This is important to know, because being water soluble means that our bodies can absorb CDP choline, while not being able to store it for later use, which happens with fat soluble supplements. In other words, our bodies are able to absorb up to 95% of an oral dose of CDP choline.

The CDP choline supplement comes in two forms: powder add capsule. It seems that our bodies are quite capable of handling this supplement, as there are many documented cases where a high oral dose of CDP choline didn’t result in any of the known and significant side effects.

A daily cumulative dose that is considered safe, yet effective ranges anywhere from 250mg to 1000mg. It is recommended to either take CDP choline in a single dose or spread it throughout the day in two doses, which can be either 12 or 8 hours apart.

Furthermore, your daily dosages will depend on the results you want to achieve and the reason why you are using CDP choline supplementation. If you are unsure about how much to take, you can always consult your doctor. Sometimes, it is better to be on the safe side.

Experts recommend that you keep your daily doses anywhere between 500mg to 1000mg if you want to achieve the cognitive benefits of CDP choline. As a side note, since CDP choline can increase energy levels, make sure not to take it before going to bed or you might experience difficulties when trying to catch some sleep.

If you are a stroke survivor or an elderly person with memory loss, you can experience more benefits when taking larger doses, but before you do so, it is strongly advised to consult your doctor ask for their dosage recommendation.

For age-related memory impairment, doses that range from 1000mg to 2000mg of CDP choline per day have shown beneficial effects. CDP choline can improve verbal memory in this case, and can also be used to improve cognitive functions in patients with Alzheimer’s disease. The recommended daily dose for these patients is 1000 mg of CDP choline.

Our bodies are able to absorb up to 95% of an oral dose of CDP choline

CDP Choline Stacking

Many people like to stack nootropics because this is an excellent way to increase and prolong their beneficial effects. CDP choline is commonly stacked with Piracetam, or Nootropyl. Piracetam is a very popular nootropic with powerful benefits and can significantly enhance cognitive functions.

The question you might ask is: “Why use these two in combination when they have similar effects?” Well, it is true, both of these nootropics supplements have approximately the same benefits, but stacking them results in experiencing more benefits, as Piracetam boosts CDP choline effects and vice versa. And, these effects are much stronger than when taking each one of these separately.

This is simply because Paracetam requires extra Acetylcholine to be present in the brain to provide beneficial effects. It connects to the Acetylcholine receptors and increases the activity of this neurotransmitter, but since we have a limited amount of Acetylcholine, Paracetam can’t reach its full potential. This is where CDP choline comes into play – it increases Acetylcholine production, thus enhancing the effect of Paracetam.

The effects of this powerful synergy are:

• Increased memory
• Better learning capacity
• Enhanced sensory perception
• Better focus
• Increased attention
• Better concentration
• Increased levels of mental energy
• Increased motivation

CDP Choline Side Effects

At the time of this writing, the FDA has still not approved CDP choline as a drug that can be used to treat or prevent any conditions, so CDP choline remains available as a health supplement. As we have mentioned earlier, our bodies have the ability to tolerate CD choline quite well, so the risk of unwanted side effects is low, but you should still take proper and advised dosages.

The side effects of CDP choline are very rare and they are very mild at most. Here are the side effects linked with CDP choline intake:

• Headaches
• Nausea
• Fatigue
• Nervousness
• Problems with the gastrointestinal tract
• Diarrhea
• Dizziness
• Drop in blood pressure (in extremely rare cases)

There are no studies that provide any evidence on the effects of CDP choline during the nursing period or pregnancy. This is why you should avoid taking this supplement in either of these cases, just to be on the safe side.

That being said, CDP choline is labeled as a supplement with a safe toxicity index, and should be considered safe to use by old and young people alike, as there is no evidence that supports the opposite claim. It has been used for decades now as a supplement that can improve attention, memory and concentration.

Where to Buy Cdp Choline

When you decide to purchase CDP choline, you have several options. Since it is a dietary supplement, it can usually be found on the shelves of better supplied store. If you are looking for a more convenient way, you can buy CDP choline online from the comfort of your own home. It is important to know that not all online vendors offer a product of the same quality and pureness.

This is why you should stick with the most reputable online shops when you are buying a dietary supplement. After all, this is your health we are talking about. You can also purchase CDP Choline Capsules or CDP Choline Powder on Amazon.

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CDP choline is a powerful nootropic with a range of powerful benefits for our health and cognitive functions. It can be safely used by both young and old people who experience problems with memory or want to improve their focus and enhance their attention and concentration.

This supplement is also known to provide benefits for patients with Alzheimer’s disease and people who have suffered from ischemia. With very mild and extremely rare side effects, CDP choline is one of the most popular nootropics.


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