COLURACETAM
Also Known As BCI-540, MKC-231
Type
  • Racetam
Good for
  • Memory
  • Learning
  • Mood
  • Creativity
  • Anxiety
Stacks Well With  

Dosage 3-35 mg
Half-life 3 hours

Coluracetam is a smart nootropic supplement from the racetam family. Research has shown that it’s a potent cognitive enhancer that can be useful in treating anxiety, major depressive disorder, and other cognitive impairments. The mental benefits include an improvement in focus, motivation, intelligence, memory, learning, and overall cognitive functions.

Summary

Coluracetam is a bit less popular than other similar products from this family. Still, this nootropic compound does have positive effects on memory and cognitive functions. It is often used to treat symptoms of manic depression and anxiety, but its effects differ from similar supplements like aniracetam and piracetam.

On the other hand, coluracetam has many similar effects as noopept, one of its distant cousins, but the effects of coluracetam are much stronger and almost twice as strong.

Out of all racetam-based nootropics, this supplement is the most difficult to manufacture. In other words, coluracetam cannot be found in any type of food, meaning, it’s a synthetic supplement. But its many benefits have put it on the list of “promising nootropics”, as it shows great potential in treating the optic nerve, retinal damage, and other central nervous system disorders.

Coluracetam is made from a racetam compound which is derived from piracetam. Because of its origin, it enhances an upsurge in choline, which is known to trigger an important neurotransmitter called acetylcholine (ACh). As a result, this neurotransmitter, which is in charge of the proper functioning of our memory, accumulates in much higher levels, leading to an improvement in alertness and attention.

Currently, the brain boosting abilities of this nootropic are mostly utilized by students, to increase their performance in school. It’s also recommended for people with a busy lifestyle who struggle to find balance and maintain focus.

Coluracetam History  

Coluracetam was first developed and officially registered by the Mitsubishi Tanabe Pharma Corporation in 2005. Known as MKC-231, the drug was used to test the effects of Alzheimer’s disease. Although the clinical trials didn’t reach the expected results, there were still signs of certain advantages in brain function.

After the first semi-failed attempt, BrainCells Inc. took over the investigation once they got the license. However, their investigation went in another direction as they tested the substance for major depressive disorder (MDD), for which they received a “Qualifying Therapeutic Discovery Program Grant” reward.

The second phase of clinical trials showed that this drug had big potential for treating people who struggle with both anxiety and a major depressive disorder. Entitled phase II for BCI-540, now known as coluracetam, it was very successful. The patients who received the drug reported a reduction in symptoms by 17%.

Coluracetam has the big potential for treating people who struggle with both anxiety and a major depressive disorder

Unfortunately, the BrainCells Inc. company didn’t continue with their trials. However, this didn’t stop many nootropic users from including this supplement in their favorite list of nootropics. Nowadays, coluracetam is available as an over-the-counter dietary supplement in the U.S.

Coluracetam’s Mechanisms of Action

Coluracetam’s chemical structure is:

2-(2-oxopyrrolidin-1-yl)-N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b] quinolin-4-yl)acetoamide

As previously mentioned, due to its basis, coluracetam shares some characteristics with other racetams. However, there are also quite a few differences as well. For example, though it increases the amount of choline in neurons, coluracetam augments impaired or damaged neurons as well.

ColuracetamThis high-affinity choline uptake is also known as HACU. The increased rate of HACU amplifies the activity of cholinergic neurons, which are directly related to cognitive functions.

Moreover, the end result is enhanced cognitive performance such as better memory, ease of learning, attention, and alertness.

Coluracetam also might be effective in the visual cortex, the area of the brain that controls visual processing (processing colors, shapes, and movement). After all, the name of this nootropic comes from its noticeable eyesight improvements such as being able to experience more vivid colors and clearer shapes.

Given that there aren’t a lot of studies that can back the full capabilities of coluracetam, we can only speculate that the use of the drug in medical treatments will be examined further in the future. But for now, while its distribution is limited and the drug is mostly available online, many nootropic experts and fellow Americans who used coluracetam claim to have experienced a positive outcome.

Coluracetam Benefits and Effects

There has been a limited amount of human testing, but some clinical trials show the most amazing potential – Coluracetam can possibly contribute to long-term memory improvements with impaired subjects. So far, most of the research done on animals brought exciting results, so let’s review all the known benefits and effects of coluracetam.

Memory and Learning Enhancements  

BrainCells Inc. studied coluracetam effects on rats who were chemically impaired. For eight days, the subjects were given 3mg of coluracetam along with a special compound, AF64A (type of neurotoxin). After conducting the standard Morris Water Maze test, the study findings concluded that there were significant improvements in learning without any negative side effects such as hypothermia, tremors, or salivation.

However, what led scientists to believe that these are long-term benefits is the fact that the rats were able to get through the maze even after 72 hours have passed since the last dose of 8 mg. So, the same effects continued for three days after the trail, confirming the prolonged cognitive advantage without any side effects.

MDD and General Anxiety Disorder  

Phase II of the BrainCells trials also found coluracetam to be effective in patients with major depressive and general anxiety disorder, who had failed in their previous treatments with common antidepressants.

After administering three daily doses of 80 mg, 240 mg in total, subjects demonstrated positive behavioral changes and improved their depression assessment scores by 36%. Without a visible change in serotonin levels, the patients successfully increased self-efficiency and found a sense of relief, which the antidepressants couldn’t provide.

Eyesight and Optic Nerve Injuries

Since previous studies found that coluracetam supports neurological functions, including impaired and damaged neurons, it’s believed that it could be used when treating optic nerve injuries and eyesight impairments. Although there are no conclusive study results to support this claim, coluracetam undoubtedly has a strong connection with our visual cortex and it exhibits different benefits.

Cognitive and Global Brain Function Improvements

A U.S. National Library of Medicine article review of cholinergic changes in Parkinson’s disease, dementia (PDD), and dementia with Lewy bodies (DLB) suggests that cholinesterase inhibitors have a positive effect on cognition, psychiatric symptoms, and general brain functions in patients with DLB and PDD.

In fact, all studies, including one big, 2 small placebo-controlled trials, and almost 20 open-label studies involving human subjects, came to the same conclusion. Considering that coluracetam increases levels of choline, we could speculate that it should be able to provide similar results. But without further studies, this remains only a theory.

Coluracetam vs. Noopept: What is the Difference?

Coluracetam is a racetam that indirectly stimulates acetylcholine. Its functions are directly related to cholinergic neurons. It increases their efficiency and therefore improves cognition.

Noopept on the other hand, doesn’t belong to the group of racetams, although it acts as a more potent version of piracetam. This compound is known for its neuroprotective abilities, especially in patients who suffered brain trauma.

While both drugs improve cognitive functions, the one thing they truly have in common is that they are both biologically active in small quantities.

Coluracetam 3-30mg
Noopept 10-30mg

Given that there aren’t a lot of studies that can back the full capabilities of coluracetam, we can only speculate that the use of the drug in medical treatments will be examined further in the future.

Coluracetam Side Effects

Once again, there is not much information or studies available on coluracetam regarding its side effects and toxicity. However, the doses presented above have shown no negative side effects and are usually well-tolerated. First-time users might experience headaches, which is a common mild side effect for any nootropic beginner.

Note: In the case you are considering taking coluracetam or any other nootropic supplement, consult a doctor before you make the final decision. Only a verified physician can determine if you need to take supplementation, which product in particular, and the proper dosage.

Coluracetam Dosage

Given that coluracetam is quite potent, smaller doses are recommended. Many nootropic users report that the correct dosage is between 3 and 35mg. However, before consumption, divide the selected dosage of coluracetam into three parts and take it three times a day.

It’s generally advised to take smaller doses at first and to gradually increase the dosage in case you don’t notice any specific effects. Those who have MDD and problems with anxiety may feel free to up their dosage to as much as 100 mg 3 times per day if they have to.

User Experience

Personally, coluracetam helped me repair my eyesight, gave me tranquility, and much better focus. I have an eye condition called astigmatisms, which basically means that my sight is awful. It’s always blurry and I can’t properly focus the light, but since I started taking and stacking coluracetam with other racetams, my vision and general state of mind drastically improved.

Knowing that nootropic effects depend on the individual, here are some other examples of what other coluracetam users have to say about their experience. In general, people tend to report that they see colors more vividly and that they feel more awake and focused. These benefits are usually experienced quite soon after taking coluracetam.

Improvements in mood and memory are often seen, and I can report that I’ve experienced similar things after a couple of days. It also helped me feel less stressed out, so I was able to concentrate fully on any task I had in front of me.

The biggest change for me personally was the fact that I was able to get a good night’s sleep for the first time in weeks. I tend to get quite anxious and can’t sleep for more than 4-5 hours a night when I have a lot of work, but coluracetam seemed to take the edge off and helped me improve my sleeping habits.

Of course, after getting enough sleep and the extra focus boost from the nootropic, I was able to think much faster, come up with creative solutions to problems and communicate my thoughts much more efficiently when talking to people.

Coluracetam Stacking  

First-time coluracetam users can try stacking this nootropic with a bioavailable choline source to reduce the chances of side effects. Like most racetams, coluracetam works great when stacked with its family, so Alpha GPC, CDP Choline, and Centrophenoxine will lessen the potential headaches that occur in some people.

Where to Buy Coluracetam

Coluracetam is not that easy to find, because it still hasn’t been properly tested. However, it never hurts to hit the Internet and check out coluracetam offers on Amazon. In order to avoid a potential hoax and to find only the best product for you, we recommend that you visit this page:

Conclusion

Coluracetam might be a less popular nootropic when compared to other racetams, but it surely has potent positive effects. As of now, several conducted trials have shown that there is potential for therapeutic use, and long-term cognitive improvements, but we will have to wait for more studies to see its full potential. Either way, nootropic enthusiast who want to unlock, enhance, and retain their cognitive abilities can take advantage of this nootropic supplement.

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