Vitamin B1 or widely known as Thiamine within the nootropics community is one of the most essential vitamins when it comes to its effects on glucose production and regulation. Even though vitamin B1 has various effects and uses and can be found in abundance within foods and drinks, it also has nootropic-like effects on improving memory, helping with chronic pain, anxiety and depression.


Vitamin B1 or Thiamine was the first ever B-Complex vitamin to be identified. This is why it was simply named B1, as it is the first of its kind. The first time that vitamin B1 was recognized as important is when Japanese scientists noticed that the population of Japan was missing something from their diet, as they were all eating polished rice.

This type of rice is a processed food and through the processing, it lost all the vitamin B1. This meant that a big part of the population had been suffering from thiamine deficiency. This caused a lot of disorders within the nervous system. Our body doesn’t create or store vitamin B1 and it can be completely depleted by our body in two weeks if not consumed from food or supplements.

It can help improve your overall mood and various brain functions. However, given the fact that vitamin B1 doesn’t pass the blood-brain barrier so easily, the nootropic community has used Sulbutiamine, a vitamin B1 derivate that has more power and better bioavailability.

Vitamin B1 Benefits and Effects

Effects of Vitamin B1

Vitamin B1 is famous for playing an active role in many different processes that happen in our body on a regular basis. First of all, vitamin B1 is essential for keeping our tissue healthy. This is owed to the fact that it creates enzyme and protein synthesis within the body.

The second crucial effect of vitamin B1 is that it improves carbohydrates metabolizing and this is one of the most important processes for producing more energy both for the body and for the brain. The body relies on a constant supply of Thiamine so that it can produce ATP, an energy format that is required in the cells.

Additionally, vitamin B1 has important roles in transporting proteins and fats throughout the body as well as regulating metabolism. Vitamin B1 is also very important for maintaining heart health. As most of you probably know, our heart is one of the busiest muscle in our body that never stops working. By taking vitamin B1 regularly, you’ll be able to improve your heart’s strength and its pumping power.

This is a very important effect for people who have some congestive heart failure issues and they should consider taking more Thiamine to improve their heart health. At the same time, it has been proven that vitamin B1 helps improve and reinforce all the nerve function that happens in our body.

Benefits of vitamin B1

The first and the most widely known benefit offered by vitamin B1 and its regular supplementation is the improvement in general mood. Unlike some other vitamins, this benefit is present whenever you take vitamin B1, even when there is no vitamin deficiency within your body.

Vitamin B1 Review

There are many studies that confirm the benefits that vitamin B1 has on overall mood, alertness, and energy. Apart from increasing the energy levels drastically, a vitamin B1 supplement also helps reduce blood pressure, helps promote better sleep, and in some cases can even help users lose weight.

There are even some signs that it could be effective for treating memory impairment, memory loss, and diseases such as Alzheimer’s, but more research still needs to be done. Thiamine also helps protect the body from many different diseases and deficiency problems. One of the condition that it can help with is beriberi which was first noted in Japan.

There are also indications that vitamin B1 can help prevent developing cataracts in people who are prone to these issues, but it’s also good to take other vitamin B’s to enhance the effects. In the end, Thiamine has also been proven to protect brain cells from alcohol damage.

How Vitamin B1 Works

Thiamine or vitamin B1 improves brain functions and its health in many different ways. However, there are the two most important functions that make Thiamine what it is. The first important function of Thiamine is that it increase thiamine pyrophosphate levels. TPP is one of the most important players in the citric acid cycle, which is important for brain function.

In this cycle, amino acids, monosaccharides, and fatty acids are broken down into smaller molecules which then produce ATP energy for the mitochondria and tissue for the whole body.

Apart from protecting the tissue, it also provides the necessary molecular building blocks which produce more brain cells.

Vitamin B1 also helps increase the production of PDH enzyme that is required for making the acetylcholine neurotransmitter. It also helps synthesize myelin that is vital for making sure that neurons can recognize and conduct various signals within the brain. Both the enzyme and citric acid cycle are important for maintaining neurotransmitters like GABA and glutamate.

What is the difference between Thiamine and Sulbutiamine

We mentioned earlier that Sulbutiamine is more powerful than Thiamine. This is a synthetic version of Thiamine and it has two B1 molecules which are bonded. The issue with vitamin B1 is that it’s water-soluble, meaning that it doesn’t go through the blood-brain barrier that easily and this is what almost all nootropics can do.

On the other hand, Sulbutiamine is not water-soluble but fat-soluble allowing it to go through the blood-brain barrier easily. Sulbutiamine has the same functions as Thiamine when in the system, however, since its bioavailability is far better it has stronger effects.

Vitamin B1 Dosage

The vitamin B1 recommended daily dosage is set at a surprisingly low amount by the FDA and the suggested dosage is no more than 1.2 mg daily. However, this dosage is recommended for people with no health issues and no vitamin B1 deficiency. For people who drink a lot of alcohol every day or have high blood sugar or blood pressure the recommended dosages are from 100 to 300 mg per day.

Women who are breastfeeding or are pregnant have a recommended dosage of 1.4 mg per day. Still, the supplements can come in 50 mg or 100 mg pills. People with a vitamin B1 deficiency can also take up to 300 mg per day, but they first need to consult their physician to ensure that this is, in fact, the case.

All these recommendations are completely safe but still, it’s important to start with caution, especially if you are taking vitamin B1 as a supplement. Start off with a small dosage so that you can see how your body reacts and make sure to consult your doctor to see whether you have some underlying issues that would make the supplementation unsafe.

Vitamin B1 Stacking

The first thing to know about stacking Thiamine is that you can combine it with other B complex vitamins. Together they can enhance your effects and give you a wider range of benefits. Some of the most valuable nutrients you should add to your supplementation or intake through food include B12, B6, and B5.

However, vitamin B1 can be stacked with other nootropics on its own to further enhance the desired effects. For example, it can be used with nootropics that give you energy and complement that effect. However, when doing this, it’s necessary to keep the dosages low.

Still, experienced neuro-hackers like to include Sulbutiamine with their nootropic stacks rather than the standard Thiamine, as it gets absorbed better into the brain and has more powerful effects overall. Still, this is not recommended for beginners and you should start off with Thiamine at first while also getting your body used to other nootropics before you start stacking and then switching to Sulbutiamine.

Vitamin B1 Side Effects

Vitamin B1 is generally considered to be a safe supplement and most people tolerate it really well. Healthy individuals almost never experience any issues with this substance and they can use it freely. Still, we won’t lie to you and tell you that Thiamine has no potential side effects. Like with any other medications, supplements or drugs, there is a possibility for several side effects, although they rarely happen.

Vitamin B1 ReviewIt’s a non-toxic substance and this is why it is so widely used. The most common side effect that can occur due to vitamin B1 supplementation is minor stomach issues that can be “fixed” in a day. Still, stomach issues almost exclusively happen when the user has been taking the vitamin in extremely high doses over a longer period of time.

Vitamin B can give you stronger and more well-rounded benefits when combined with other B complex vitamins, so it’s best to always use them together.

The biggest side effect so far has been related to using vitamin B1 with Digoxin and similar heart medications, as well as diuretics. If you are using these medications make sure to consult your doctor before taking vitamin B1.

Our experience

As big nootropics enthusiasts we don’t just promote supplements through other people’s experiences and by relying on studies. If we think that something is worth trying out for improving your energy and helping you stay active during the day, we like to try it out ourselves. This is why we also tried Thiamine to see whether it works like people say it does.

Even though my diet includes a lot of wheat products, which contain vitamin B1, I tried Sulbutiamine a couple of times. I immediately switched to this version as I used a lot of nootropics in the past and still do so. When I was using Sulbutiamine I skipped using other nootropics so that could I clearly see what its effects were.

Even though I use stronger nootropics to get the necessary energy I need during a busy day, I certainly felt similar effects with Sulbutiamine. However, the most surprising thing was the motivation boost it had.

Nothing I had to do seemed difficult to me and I actually even enjoyed certain things I usually don’t like doing. I was actually surprised by the positive effects of this supplement and, to me, it seems like it even affects dopamine receptors, but this is just my opinion.

Where to Buy Vitamin B1

Thiamine is an important nutrient that can be found in many different foods in grocery stores and in supplement shops. It can be taken through regular food or as a supplement. However, if you want to get better brain enhancement effects, then it’s probably better to take supplements. Still, it’s important that your regular diet also includes food that has it.

When it comes to supplements, they can also be ordered online and they come in many varieties and combinations with other B complex vitamins. It’s important to check the ingredients and ensure that the supplement is top quality and offered by a reliable vendor.

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If your diet has plenty of vitamin B1 from seeds, nuts, and wheat products, then chances are that you don’t really need to supplement it. In this case, you can add a standard 1 mg per day of supplementation, but still, it would be better to get the same effects from some other nootropics.

However, people who need vitamin B1 the most are those who don’t have well-rounded diets and don’t get enough of it. Other groups of people who should supplement their diets with Thiamine are alcoholics, diabetics, and prediabetics.


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