Picamilon (nicotinyl-y-aminobutyric acid, or N-nicotinoyl-GABA) is a nootropic composed of the inhibitory neurotransmitter GABA and nitronic acid. Nitronic acid (Vitamin 3 or niacin) allows neurotransmitter GABA to cross the blood-brain barrier.
After neurotransmitter gamma-aminobutyric acid (GABA) crosses the blood-brain barrier, it activates GABA receptors for producing an anxiolytic response. Niacin improves blood flow in the brain and acts as a vasodilator, relaxing constricted blood vessels.
Picamilon was developed in Russia in 1969, but it has been used since 1986 for treating learning, memory, and attention problems. Also, it has been used as a pharmaceutical for the treatment of loss of brain blood circulation, chronic alcoholism and brain trauma.
- 1 Summary
- 2 Picamilon Benefits and Effects
- 2.1 Body relaxation
- 2.2 Picamilon helps balance mood
- 2.3 Picamilon can boost cerebral circulation
- 2.4 Picamilon improves vision
- 2.5 Picamilon against nerve inflammation (Neuropathy)
- 2.6 Picamilon lowers blood pressure
- 2.7 Picamilon may improve memory
- 2.8 Picamilon may protect the brain
- 2.9 Picamilon boosts brain cell mitochondria function
- 2.10 Picamilon improves sleep
- 2.11 Picamilon may help in the treatment of Parkinson’s disease:
- 3 Picamilon Side Effects
- 4 Picamilon Dosage
- 5 Where to Buy Picamilon
- 6 Conclusion
Today, more than 30 years later, picamilon has widespread use. Adults use it as a vasoactive and nootropic drug. The drug is indicated as a tranquilizer for states of fear, anxiety, emotional stress, and increased irritability. Also, it’s commonly used in the treatment of acute cerebrovascular disturbances of mild severity, vegetovascular dystonia, and chronic cerebrovascular insufficiency.
Picamilon has been proven to work well for people with depressive disorders, for senile psychoses, and other stress-related states of mind.
Just like other nootropics, picamilon boosts brain function, improves general productivity, attention span, motivation, concentration, and memory. Besides, this multifunctional nootropic has another important role. Picamilon significantly reduces feelings of stress, anxiety, and depression. Picamilon is great because after consumption users also feel calm and relaxed.
|Picamilon at a Glance|
|Also Known As||Pycamilon, Pikamilon, N-nicotinoyl-GABA|
|Typical Dose||100–200 mg|
In Russia, picamilon is used for the treatment of many different diseases and conditions, from a migraine and depression to certain types of glaucoma, senile psychosis, and even acute alcohol intoxication.
Chronic alcoholics often use picamilon to abolish withdrawal symptoms. Picamilon reduced symptoms like apathy, weariness, and lethargy. These patients become less fussy and anxious, more tranquil and their working capacity improved.
Until 2015, picamilon was considered as a dietary ingredient. Since dietary supplements are regulated as food which can be sold directly to customers, without a label for diseases treatment, the US Food and Drug Administration limited the use of picamilon only as physical and cognitive performance products.
According to the FDA’s review, picamilon does not satisfy the definition of a dietary ingredient. Therefore, FDA does not consider picamilon to be either an old dietary ingredient or a new dietary ingredient,” said Marianna Naum, Ph.D., to NutraIngredients-USA.
Given the fact that picamilon isn’t dietary supplement, today you can use it as a medication. There are a lot of benefits and positive effects of picamilon use.
Picamilon Benefits and Effects
Although picamilon isn’t a sedative, some users noticed that they felt relaxed after consumption of this nootropic without side effects as grogginess and the mental fog that are common effects of sedative consumption. Since picamilon has no serious side effects and it’s considered a safe drug, you can take it and relax your mind and body. Balanced GABA levels in your brain will make you feel relaxed and calm.
Picamilon helps balance mood
Since picamilon raises GABA levels in the brain, it has an inhibitory effect on stimulated neurons. GABA in the brain slows excitatory communication between neurons. Low levels of GABA lead to depression, anxiety, restless thinking, and insomnia.
Picamilon, thanks to GABA, helps restore that balance. That way, increased levels of GABA alleviates all these symptoms.
Picamilon can boost cerebral circulation
Picamilon can boost cerebrovascular activity because niacin (nicotinic acid) enhances oxygen supply in the brain and cell metabolism and boosts blood flow.
Picamilon improves vision
A study published on US National Library of Medicine website shows that picamilon may improve vision. In a study of 60 patients with macular degeneration, a three-month-long treatment with picamilon improved visual acuity.
Since the macula is the central part of the retina where vision is sharpest, consumption of picamilon directly affected and improved this medical condition, also known as age-related macular degeneration (AMD or ARMD). Macular degeneration may result in blurred vision in the center of the visual field.
Picamilon against nerve inflammation (Neuropathy)
Picamilon may reduce inflammation of the nerves. It also protects nerves against inflammation.
Picamilon lowers blood pressure
Picamilon might be helpful in people with hypertension caused by stress or anxiety. Consumption of picamilon isn’t recommended for people with hypotension because it might lower their already low blood pressure. If your hypertension isn’t chronic and only happens from time to time due to stressful situations, picamilon can normalize your blood pressure.
The scientists compared how papaverine (vasodilator) and picamilon affect cerebral blood flow. They found that picamilon had a stronger blood pressure-lowering effect compared with papaverine (opium alkaloid antispasmodic drug).
Picamilon may improve memory
A study published in the Bulletin of Experimental Biology and Medicine shows that picamilon can improve both long-term and short-term memory. Scientists tested the effect of amiridin, tacrine, piracetam, and picamilon on intact rats. Amiridin, tacrine, and picamilon significantly increased long-term memory, but only picamilon enhanced short-term memory.
If you lose your concentration during learning or working, picamilon might help you. Don’t be afraid to boost your brain and improve your memory because this safe nootropic provides a lot of good benefits. Just consult your doctor about the dosage.
Picamilon may protect the brain
Picamilon protects neurons from being overactivated, which can leave to excitotoxicity. Also, picamilon increases mitochondrial function in the brain cells. A study was done on the rats who have sustained brain trauma.
Also, picamilon protects the brain and immune cells by preventing oxidative stress and cell membrane damage.
Picamilon boosts brain cell mitochondria function
Mitochondria are cellular organelles with very important function – production of adenosine triphosphate (ATP). The cells use ATP as a source of energy. Mitochondria have two membranes – the outer membrane which is smooth and the inner wrinkled membrane.
The inner membrane forms crystals with the important function of enlarging the size of the inner membrane. Mitochondria have their own DNA (Deoxyribonucleic acid) and they can duplicate themselves independent from the cell. The existence of mitochondria and eukaryotic cells is an example of eukaryotic – prokaryotic symbiosis.
Nootropics like picamilon are able to boost energy production of ATP from NADH. In that way, picamilon helps mitochondria produce ATP. A study done on the rats with oxidative damage done on brain mitochondria shows that picamilon has a protective effect on the function of brain mitochondria.
Since picamilon increases blood supply, blood circulation, and oxygen saturation in the brain, the blood flow is able to bring the nutrients and necessary oxygen to ATP that power brain cell mitochondria.
Picamilon improves sleep
Insomnia is a common problem and it’s a complicated condition. A lot of people suffer from insomnia. Since insomnia and other problems which this condition brings may last for so long, consumption of sedatives isn’t recommended. There are a lot of natural ways that can be helpful. Nootropics, especially picamilon are very effective.
Daily stressful situations and concerns are often responsible for this problem. Picamilon is effective either for periodical insomnia and for chronic insomnia which can be a nightmare even when we’re awake.
Although it sounds weird, picamilon improves sleep and boosts energy at the same time. Since picamilon isn’t a sedative or a muscle relaxer, this effect might be due to anti-anxiety and stress relief properties of this nootropic.
Picamilon may help in the treatment of Parkinson’s disease:
A study done in Ukraine on rats shows that picamilon can be helpful in the treatment of Parkinson’s disease. Results of decreased dopamine uptake by brain nerve endings and content of serotonin and dopamine under experimental parkinsonism confirms that GABA can normalize these parameters.
Since picamilon normalized dopamine uptake, scientists consider that it can be useful for treating Parkinson’s disease.
Picamilon Side Effects
Picamilon is considered totally safe when is taken in recommended doses and it has very low toxicity but some side effects have been reported. Feel free to use picamilon and medications with picamilon in agreement with your doctor.
There are no recorded cases of toxic effects, but very rare side effects are allergic reactions and skin rashes. Typically recorded side effects are dizziness, nausea, and headache. These side effects are mostly caused by high picamilon consumption. A common side effect of niacin is a red flushing of the skin.
Since picamilon lowers blood pressure, it’s not recommended for people with already low blood pressure (hypotension).
Interaction with other drugs:
Avoid drinking alcohol in combination with nootropics because mixing alcohol with picamilon may increase negative side effects. You are trying to boost your brain using picamilon, so alcohol isn’t recommended.
Picamilon is safe for use with other supplements or nootropics. The combination of picamilon and ampakine racetam supplements such as oxiracetam and aniracetam may enhance effects of picamilon. If you combine picamilon with valerian, calming properties of picamilon also might be stronger.
Every medication that modulates GABA receptors can alter the effects of picamilon:
- Non-benzodiazepines (psychoactive drugs that are benzodiazepine-like)
Interactions of niacin with other drugs:
- High-dose aspirin
- Uricosuric agents
Although picamilon has no serious side effects, you must be careful. As we mentioned, large doses of picamilon may cause certain side effects.
Dosage is different for treatment of different diseases and conditions. Typical daily dosage is between 50 and 400 mg, but most users consider that dosage between 100 and 200 mg in three separate instances is enough.
For example, the recommended daily dosage for anxiety, fear or emotional stress is 50 mg in two or three separate instances.
Since the effect of picamilon lasts between 4 and 6 hours, you will achieve the best results if you divide consumption into three instances.
Picamilon is usually produced in 10, 20 and 30 mg tablets, but you can also find it in a powder form.
Before you decide to use picamilon consult your doctor, but you can see the following recommended dosage:
- Discirculative encephalopathy – 20-50 mg per day in three instances, for the duration of up to 6 months.
- Prevention of migraines – tablets of 50 mg three times per day.
- Asthenic states – 40-80 mg per day, in unusual cases up to 300 mg, but no longer than 1.5 months.
- Depressive states – 40-200 mg per day in two or three instances, for the duration of up to 3 months.
- Improving working ability – 60-200 mg per day, for the duration up to 1.5 months.
- Alcoholism in a period of abstinence – 100-150 mg per day for the duration of 6-7 days, for longer periods the recommended dosage is 40-60 grams per day.
- Treatment of primary open-angle glaucoma – 50 mg three times per day for the duration of 1 month.
- Functional disorders of urination in children – 20 mg two times per day for children 3-10 years old, 20 mg three times per day for children older than 10.
Where to Buy Picamilon
Although picamilon is an approved medication in Russia, you can’t buy it in the United Kingdom legally. As other nootropics, picamilon is an illegal drug in some states. Try to find it online (link here), but consider the fact that it might be illegal in your state.
Find out some information about low in your country and if it’s legal, hurry up and buy it at in the nearest pharmacy.
The increased popularity of this nootropic is justified. A drug that makes you feel relaxed and energized at the same time with minimal side effects is definitely a good option to try out. This safe and well-tolerated substance can improve a lot of mental conditions, as well as physical diseases.
Besides, you can take it preventively if you are feeling anxious, depressed or even if you are exposed to stressful everyday situations. It’s safe for use even in combination with other supplements.
Picamilon has more good than bad features so you can take it daily without fear of dependence or other problems that sedatives can cause. It offers a lot of benefits that are hard to beat.