As nootropics are no longer a taboo, there is more and more interest in these cognitive enhancers. A lot of people are open to trying out nootropics and seeing what the benefits are.  However, there really isn’t a lot of clarity online, especially for those who are inexperienced and don’t have any knowledge about these drugs.


Even though the demand for nootropics has exploded, most people aren’t well informed about which nootropics are the safest to use. Even though a lot of nootropics have no or mild side-effects, there are others that are yet to be tested and researched to determine their effects. Simply put, taking some nootropics is completely safe but it doesn’t mean that you should be taking all of them.


The first nootropic that we are going to talk about is the first nootropic that was ever synthetized – Piracetam. It was first created in 1964 by Corneliu Giurgea, who is also the first person to introduce the drugs called “nootropics” and present them to the world. Even though Piracetam is often purchased as a supplement throughout the US, it’s still not completely legalized.

On the other hand, it’s a well-known prescription drug in many countries around Europe, South America, and Russia. As it is the oldest nootropic, it’s also the most researched one and there more than one hundred studies on Piracetam that you can find online. All the studies have confirmed that it is a very safe to use drug.

Additionally, Piracetam is also the best-known nootropic and the most widely used type, as most people who try out nootropics for the first time start off with Piracetam. In countries where this nootropic is legal, physicians and doctors monitor users and their behavior related to Piracetam and none of them has confirmed any severe side-effects.

The potential side-effects of Piracetam are very rare and mild. If they do occur, it’s usually because users take too high dosages but the side-effects are short-lasting. This is one of the reasons why so many new people who get into the world of nootropics start off with Piracetam.

Where to buy

No matter which country you are in and what the legal status of Piracetam is, you can purchase it online from reliable vendors in various forms.

What are the Safest Nootropics?Caffeine

Maybe this comes as a surprise to you, but caffeine is also a nootropic. As you might know, caffeine is a very popular psychoactive substance and it’s consumed all over the world in large quantities, mostly in the form of coffee. Some of the other sources of caffeine are tea, cocoa, guarana, different types of sodas, energy drinks, and kola nuts.

The reason caffeine is considered to be a nootropic is that it has the mechanisms typical to nootropics and it affects brain receptors. More accurately, caffeine blocks adenosine receptors, which subsequently leads to the user feeling fresh and less tired. Caffeine is a nootropic but we all associate it with coffee and there are very few people in the world who haven’t consumed it at some point.

Naturally, there are even more studies on caffeine than on Piracetam and due to its long history of use the studies and research are very extensive. When used in normal dosages, caffeine is well tolerated by most people and there are basically no side-effects. A recommended daily dose of caffeine is from 40 mg to a maximum of 300 mg.

Just think about it, chances are you drink coffee or tea with caffeine on a daily basis and you probably haven’t hide any side effects. Even if they occurred, they were caused by something else within the beverage. However, surprisingly when going over the recommended limit caffeine has some of the strongest side-effects that include headaches, anxiety, and hypertension.

Where to buy

Caffeine is a completely legal substance, in most countries at least. You can take it from various substances or find it alone in pills as well. However, to make the most of its effects, you can order these stacks with caffeine online.

Alpha Brain

This is one of the most popular nootropic stacks on the market today and if you find a list of suggested nootropics to start with, chances are you will find it there. One of the reasons for this is that it’s very safe to use. Alpha Brain is popular with beginners and intermediates in the nootropic world and helps improve memory, focus, and cognitive functions.

The safety of this stack can be guaranteed because the manufacturer provides information on all the ingredients. Alpha Brain has 12 different ingredients including natural nutrients like L-Theanine, L-Tyrosine, Phosphatidylserine, and Pterostilbene.

All the ingredients combined lead to the variety of benefits that this stack offers. Additionally, other ingredients like Alpha GPC, Vinpocetine, and Huperzine A have all been clinically tested and proven to have positive health effects. At the same time, these ingredients have their FDA approval as safe.

Where to buy

Even though Alpha Brain is a legal substance, this stack can be difficult to obtain because there is still a small number of producers out there. It can be difficult to find it in a local store and this I why it’s best to order it online from a reliable vendor.


Like Piracetam Aniracetam is also a Racetam class nootropic. One of the requirements for a substance to be considered a Racetam is for it to have an effect on improving cognitive functions while not having adverse effects or big side-effects. Aniracetam is considered to be completely safe and has non-toxic effects, while most users don’t feel any side-effects.

There are potential side-effects such as headaches, mild anxiety, nausea, or insomnia. Still, most users tolerate it well and don’t experience any troubles.

All of the side-effects are caused by depletion of choline. All Racetams have this effect and the solution is quite simple, either use smaller dosages or add a choline supplement to your stack and you will feel no side-effects.

Aniracetam is very similar to its older brother when it comes to safety and side-effects because it has similar effects and functions. However, the dosages are not the same and you shouldn’t make mistakes when it comes to this. The people who experienced issues with Aniracetam usually exceeded dosages or simply didn’t add choline to their supplementation.

Where to buy

Even though it might be difficult to find Aniracetam locally, in just 48 hours you can get yours by ordering from an online vendor. However, it’s essential to get the right size and find a good manufacturer.


Earlier we mentioned L-Theanine as part of the Alpha Brain stack. L-Theanine is basically an amino acid which is completely natural. It can be found in green tea and one of the reasons why this drink is considered to be good is because of its effects.

L-Theanine also has nootropic properties, as it relaxes users without making them feel sedated. This means that users can have clear thoughts without becoming overstimulated and that’s why it’s taken as a supplement.

What are the Safest Nootropics?

In the United States L-Theanine can be bought as a supplement and the FDA has given it the GRAS status which stands for “generally regarded as safe”. The FDA gives this status to substances that have enough scientific evidence showing that it can be safely consumed, as well as sold in stores commercially.

The safety profile of L-Theanine is excellent and it has mild and recognizable effects, which is why it’s a perfect nootropic for beginners.

L-Theanine and caffeine are separate nootropics but together they work especially well and this is why Alpha Brain, amongst other stacks, combines these two. They work together in a synergy, supporting each other’s effects leading to even greater benefits without any side-effects.

Where to buy

L-Theanine can be purchased and found in many different drinks or foods. However, to make the most of it, you’ll need to get supplements, as you don’t want to drink 2 liters of green tea every day. You can find the best options in online stores.


By their own definition, nootropics are safe. A supplement cannot be considered a nootropic unless it’s a non-toxic substance. For the majority of users, nootropics are tolerable and people don’t experience any issues. However, there is always that small portion of people who have some sort of bad reaction when they try something new, and this is not only about nootropics.

No matter if you’re trying some new food, drug or a deodorant, there’s a chance for an adverse reaction. The nootropics that we mentioned today are non-harmful if taken responsibly.

This is why, before using them, you should first learn more about them, the dosages, and whether you are allowed to take them. Consult your medical professional and talk to them about the supplement you plan on taking to make sure that you are good to go and you will be fine.


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